Kidney xenotransplantation: status quo and development trend of physiological research
10.3969/j.issn.1674-7445.2023148
- VernacularTitle:异种肾移植：生理学研究的现状及发展趋势
- Author:
Jiahua SONG
1
;
Yifan YU
2
;
Wenyi DENG
2
;
Xiangqin SONG
2
;
Shuai JIN
2
;
Tao LI
2
;
Kun QIAN
1
;
Yi WANG
2
,
3
,
4
Author Information
1. Department of Urology, the Second Affiliated Hospital, University of South China, Hengyang 421001, China.
2. .
3. Department of Urology, the Second Affiliated Hospital, University of South China, Hengyang 421001, China
4.
- Publication Type:ReviewArticle
- Keywords:
Xenotransplantation;
Kidney transplantation;
Renin-angiotensin-aldosterone system (RAAS);
1，25-dihydroxy vitamin D3;
Erythropoietin (EPO);
Non-human primate;
Subclinical research;
Physiology
- From:
Organ Transplantation
2023;14(6):898-904
- CountryChina
- Language:Chinese
-
Abstract:
Organ transplantation is the most effective treatment for all categories of end-stage organ diseases. To resolve the shortage of donors in organ transplantation, widespread attention has been diverted to xenotransplantation. At present, clinicians mainly highlight the problems related to xenotransplantation rejection and viral infection. The physiology of xenotransplantation has been rarely studied. Kidney performs endocrine function by producing erythropoietin (EPO), renin and activating vitamin D. Although these pathways are usually well preserved in allogeneic transplantation, species-specific differences, especially those between pigs and non-human primates, may still affect the physiological function of transplant organs. In this article, the changes of EPO, renin-angiotensin-aldosterone system (RAAS) and active vitamin D3 of pig and human after xenotransplantation were illustrated, aiming to provide reference for subclinical research of xenotransplantation.
