Research advance in the mechanism exploration of traditional Chinese medicine regulating mucus barrier and interfering with ulcerative colitis based on the “thickening intestine”theory
- VernacularTitle:基于“厚肠”理论的中医药调控黏液屏障干预溃疡性结肠炎的机制研究进展
- Author:
Jinxin WANG
1
;
Liqun LI
2
;
Xiaoyan HUANG
2
;
Maoguang HUANG
1
;
Feng LUO
1
;
Yueying CHEN
1
;
Yuling LI
1
;
Sheng XIE
3
;
Yuanyuan LIU
3
Author Information
1. School of Graduate，Guangxi University of Traditional Chinese Medicine，Nanning 530001，China
2. Second Area of Department of Spleen and Stomach Diseases，the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine，Nanning 530023，China
3. Center for Chinese Medicine Disease Prevention，the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine，Nanning 530023，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
ulcerative colitis
- From:
China Pharmacy
2023;34(21):2671-2677
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis （UC） is a clinical chronic intestinal disease， and the damage of the intestinal epithelial mucus barrier is an important pathological mechanism of UC. Mucin 2 （MUC2） is a major component of the intestinal mucus barrier， and goblet cells are the “main force” of MUC2 secretion， maintaining and renewing the intestinal mucus layer to ensure its integrity. Therefore， repairing the intestinal mucus barrier by promoting the synthesis of MUC2 by goblet cells is an important strategy for the treatment of UC. Traditional Chinese medicine scholars believe that there is an inherent layer of “lipid membrane” or “fat paste” in the intestine， and pathological factors such as moisture and heat lead to the thinning of this structure， which is the fundamental pathogenesis of “diarrhea” and “intestinal dysentery”. It coincides with the damage of intestinal mucus barrier leading to UC in modern medicine. Based on this， this paper summarized the mechanism of Chinese herbal compounds or Chinese herbal active components in regulating intestinal mucus barrier to interfere with UC. It was found that Chinese herbal compounds such as Huanglian jiedu decoction， Shaoyao decoction and Compound Kusen decoction， as well as Chinese herbal active ingredients such as volatile oil of Atractylodes lancea， paeoniflorin and papaya triterpenes could promote the synthesis and secretion function of goblet cells， and achieve the purpose of “thickening intestine”， thus relieving UC symptoms.
