Network meta-analysis of the effectiveness and safety of 3 kinds of snake venom hemocoagulase drugs for hemostasis in abdominal surgery
- VernacularTitle:3种蛇毒血凝酶类药物用于腹部手术止血有效性和安全性的网状Meta分析
- Author:
Zihui ZHENG
1
;
Huijie PAN
2
;
Zinan ZHAO
1
;
Xin HU
1
;
Pengfei JIN
1
Author Information
1. Dept. of Pharmacy，Beijing Hospital/ National Center for Gerontology/Institute of Geriatrics，Chinese Academy of Medical Sciences/Beijing Key Laboratory for Clinical Risk and Individualized Application Evaluation of Drugs （Beijing Hospital），Beijing 100730，China
2. Dept. of Laboratory，Beijing Hospital/National Center for Gerontology/Institute of Geriatrics，Chinese Academy of Medical Sciences，Beijing 100730，China
- Publication Type:Journal Article
- Keywords:
snake venom hemocoagulase;
abdominal
- From:
China Pharmacy
2023;34(21):2631-2637
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To systematically evaluate the hemostatic effect and safety of snake venom hemocoagulase drugs in abdominal surgery， so as to provide evidence-based evidence for clinic. METHODS Retrieved from Embase， Cochrane Library， PubMed， China Biomedical Literature Database， CNKI and Wanfang database， randomized controlled trials （RCTs） about 3 kinds of snake venom hemocoagulase drugs （Hemocoagulase injection， Hemocoagulase Bothrops atrox for injection， Haemocoagulase Agkistrodon for injection） in abdominal surgery were collected from the establishment of the database to Aug. 2023. Screening， quality evaluation， and data extraction were conducted on literature according to the inclusion and exclusion criteria， and Cochrane 5.1 was used for literature quality evaluation. The risk bias diagram and network diagram were drawn by Stata 15.1 software， and the Bayesian network meta-analysis was carried out by using R 3.6.2 software and Markov chain-Monte Carlo method. RESULTS A total of 11 studies were included， involving 1 401 patients， 852 in the study group， and 549 in the control group. In terms of hemostatic effect， Hemocoagulase injection was significantly superior to Haemocoagulase Agkistrodon for injection [MD＝－2.45， 95%CI （－4.39，－0.24）， P＜0.05]， and the probability of reducing intraoperative bleeding was ranked as follows： Hemocoagulase injection＞hemocoagulase B. atrox for injection＞Haemocoagulase Agkistrodon for injection； in terms of safety， there was no statistically significant difference between the three snake venom hemocoagulase drugs and placebo （P＞0.05）. CONCLUSIONS The hemostatic effect of Hemocoagulase injection in abdominal surgery is significantly better than that of Haemocoagulase Agkistrodon for injection； all three snake venom hemocoagulase drugs have good safety.
