Thromboelastography Parameter and Its Association with Survival of COVID-19 Patients: A Retrospective Cross-Sectional Study
https://doi.org/10.47836/mjmhs.19.4.19
- Author:
Nita Wiyono
1
;
Yetti Hernaningsih
1
;
Arifoel Hajat
1
;
Paulus Budiono Notopuro
1
;
Narazah Mohd Yusoff
2
,
3
;
Emmanuel Jairaj Moses
3
Author Information
1. Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Hospital, Surabaya, East Java, Indonesia
2. Advanced Medical and Dental Institute, USM, Kepala Batas 13200, Penang, Malaysia&
3. Department of Biomedical Sciences Advanced Medical and Dental Institute, University Sains Malaysia, Penang, Malaysia
- Publication Type:Journal Article
- Keywords:
COVID-19, Hypercoagulability, Thromboelastography, Fibrinolysis, Survival
- From:Malaysian Journal of Medicine and Health Sciences
2023;19(No.4):124-129
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Coagulopathy associated with Coronavirus disease 2019 (COVID-19) may cause life-threatening complications, especially in severe or critically ill COVID-19 patients. Thromboelastography (TEG) is an effective, dynamic, and reliable test to assess the complete coagulation process. This study aimed to determine the association
between selected TEG parameters and survival in COVID-19 patients. Methods: This study was a retrospective
observational study using data from medical records of COVID-19 patients who were hospitalized in Dr. Soetomo
Hospital, Surabaya, Indonesia. There were 94 COVID-19 patients consisting of 76 survivors and 18 non-survivors.
The association between TEG results and certain TEG parameters with survival status was considered significant if
the p-value ≤ 0.05. Results: Increased coagulation activity had a significant association with the survival status of
COVID-19 patients (p=0.04). There were no significant differences in all TEG parameters between COVID-19 patients who survived and those who did not survive (p > 0.05). Based on the TEG analysis tree, the most TEG results
found were secondary fibrinolysis (21.3%) and fibrinolytic shutdown (24.5%). No significant association was found
between the coagulability and fibrinolysis abnormality with the survival status in COVID-19 patients (p > 0.05).
Conclusion: There was no significant difference in TEG results between COVID-19 survivors and non-survivors.
However, based on the TEG result, an increase in coagulation activity is associated with a lower survival rate. Further study with detailed timing of TEG examination, disease severity and comorbidities stratification in COVID-19
patients may be needed.
- Full text:11.2023my1570.pdf
