Effects of growth hormone on glucose metabolism and insulin resistance in human.
10.6065/apem.2017.22.3.145
- Author:
Shin Hye KIM
1
;
Mi Jung PARK
Author Information
1. Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea. PMJ@paik.ac.kr
- Publication Type:Review
- Keywords:
Growth hormone;
Glucose;
Metabolism;
Insulin resistance
- MeSH:
Glucose*;
Growth Hormone*;
Humans*;
Hyperglycemia;
Insulin Resistance*;
Insulin*;
Liver;
Metabolism*;
Pancreas
- From:Annals of Pediatric Endocrinology & Metabolism
2017;22(3):145-152
- CountryRepublic of Korea
- Language:English
-
Abstract:
Growth hormone (GH) is important for promotion of somatic growth and the regulation of substrate metabolism. Metabolic action of GH occurs in multiple tissues including the liver, muscle, fat and pancreas either directly or indirectly through insulin-like growth factor 1. The diabetogenic action of GH has been well-described in previous in vivo studies. In this paper, we review the metabolic effects of GH on peripheral tissues focusing on glucose metabolism and insulin resistance, and discuss results from human studies on the long-term effects of GH administration on insulin resistance and hyperglycemia.
