The triglyceride-to-high density lipoprotein cholesterol ratio in overweight Korean children and adolescents.
10.6065/apem.2017.22.3.158
- Author:
Dong Yoon YOO
1
;
Yu Sun KANG
;
Eun Byul KWON
;
Eun Gyong YOO
Author Information
1. Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea. pedyoo@cha.ac.kr
- Publication Type:Original Article
- Keywords:
Dyslipidemia;
Obesity;
Hypertriglyceridemia;
Insulin resistance;
Child;
Adolescent
- MeSH:
Adolescent*;
Alanine Transaminase;
Child*;
Cholesterol*;
Dyslipidemias;
Fasting;
Glucose;
Homeostasis;
Humans;
Hypertriglyceridemia;
Insulin;
Insulin Resistance;
Lipoproteins*;
Obesity;
Overweight*;
Prevalence;
Sensitivity and Specificity
- From:Annals of Pediatric Endocrinology & Metabolism
2017;22(3):158-163
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio has recently been reported as a biomarker of cardiometabolic risk in obese children and adolescents. The purpose of this study is to describe the TG/HDL-C ratio and related factors in overweight and normal weight Korean children and to evaluate whether the high TG/HDL-C ratio is associated with insulin resistance in overweight children and adolescents. METHODS: Data from 255 overweight (aged 8.7±2.0 years) and 514 normal weight (aged 8.9±1.8 years) children and adolescents were evaluated. Glucose, insulin, total cholesterol (TC), HDL-C and TG levels were measured after overnight fasting, and the TG/HDL-C ratio, non–HDL-C and the homeostasis model assessment of insulin resistance (HOMA-IR) were calculated. RESULTS: The TG/HDL-C ratio was higher in overweight group compared to normal weight group (P < 0.001). Among overweight children and adolescents, alanine aminotransferase (P=0.018), non–HDL-C (P < 0.001), and HOMA-IR (P=0.004) were different between the TG/HDL-C ratio tertile groups. The prevalence of elevated HOMA-IR was increased with increasing TG/HDL-C ratio tertiles (P for trend=0.003). On regression analysis adjusted for age and sex, the BMI (β=0.402, P=0.001) and TG/HDL-C ratio (β=0.251, P=0.014) were independently associated with HOMA-IR (adjusted R2=0.324). The TG/HDL-C ratio of 2.0 or more showed higher sensitivity (55.6%) and specificity (72.9%), when compared to TC (≥200 mg/dL), non–HDL-C (≥145 mg/dL), and LDL-C (≥130 mg/dL) for identifying overweight children with elevated HOMA-IR. CONCLUSION: The TG/HDL-C ratio is independently associated with insulin resistance in overweight children and adolescents, and it can be useful in identifying those at higher cardiometabolic risk.
