Tualang and Kelulut Honey Reduced Lipopolysaccharidesstimulated Inflammatory Responses of Mic
https://doi.org/10.47836/mjmhs.19.3.47
- Author:
Low Zhao Xuan
1
,
2
;
Tan Kai Li
1
,
2
;
Yong Yoke Keong
3
;
Looi Chung Yeng
1
,
2
;
Ooi Yin Yin
1
,
2
Author Information
1. School of Biosciences, Faculty of Health and Medical Sciences, Taylor&rsquo
2. s University, 47500 Subang Jaya, Selangor, Malaysia
3. Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
- Publication Type:Other Types
- Keywords:
Tualang honey, Kelulut honey, Microglia, Neurodegenerative disease, Inflammation
- From:Malaysian Journal of Medicine and Health Sciences
2023;19(No.3):375-379
- CountryMalaysia
- Language:English
-
Abstract:
Microglial activity is crucial in maintaining the central nervous system (CNS) homeostasis. However, prolonged
microglial activation have been implicated in the pathology of neurodegenerative diseases. Activated microglia will
increase the production of inflammatory cytokines, reactive oxygen species (ROS) and alter their surface marker
expression levels. This study used Malaysian honey, Tualang honey (TH), and Kelulut honey (KH) to determine lipopolysaccharide (LPS)-stimulated inflammatory responses of microglia. TH and KH at 0.1% were used in the current
study as our findings showed no significant difference in the cell viability between BV2 cells treated with 0.1 % of
TH and KH and control group. TH and KH reduced the ROS level significantly by 41.62±1.06% and 49.16±0.63%,
respectively, and slightly reduced the expression of co-stimulatory molecules, CD40 and CD11b in LPS-activated
BV2 cells. Our preliminary findings proposed an in-depth future study on the anti-inflammatory effect of TH and KH
on microglial activation.
- Full text:11.2023my1547.pdf
