Traditional Chinese Medicine Treats Hepatic Fibrosis via NF-κB Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20231244
- VernacularTitle:中医药基于NF-κB信号通路治疗肝纤维化的研究进展
- Author:
Zishun LI
1
;
Changpu ZHAO
2
;
Renwu CHEN
1
;
Meiling LI
1
;
Fei WANG
1
;
Chenyuan HAO
1
Author Information
1. The Second Clinical Medical School of Henan University of Chinese Medicine， Zhengzhou 450002， China
2. Henan Provincial Hospital of Traditional Chinese Medicine， Zhengzhou 450002， China
- Publication Type:Journal Article
- Keywords:
hepatic fibrosis;
nuclear factor-κB （NF-κB） signaling pathway;
traditional Chinese medicine;
inflammation;
anti-fibrosis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(23):275-282
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic fibrosis is a common complication of chronic liver disease， seriously affecting patients' quality of life and leading to severe consequences such as cirrhosis and liver cancer. Modern medicine has made progress in the treatment of hepatic fibrosis， while it still faces certain challenges and limitations. Therefore， seeking new therapeutic strategies is of great clinical significance. The nuclear factor-κB （NF-κB） signaling pathway plays a role in regulating inflammation and immune responses. Recent studies have shown that the NF-κB signaling pathway plays a key role in the occurrence and development of hepatic fibrosis. The abnormal activation of the NF-κB signaling pathway leads to the overexpression of genes related to liver inflammation and fibrosis， thereby promoting the development of hepatic fibrosis. Traditional Chinese medicine （TCM） is a traditional treatment method with unique advantages and potential. In recent years， increasing studies have proved that TCM can treat hepatic fibrosis by regulating the NF-κB signaling pathway. The active ingredients in Chinese herbal medicines can intervene in the activation of the NF-κB signaling pathway to inhibit inflammatory responses， thereby reducing the severity of hepatic fibrosis. This article reviews the mechanisms of TCM in treating hepatic fibrosis via the NF-κB signaling pathway and evaluates the efficacy and discusses the clinical application prospects of relevant Chinese herbs and formulae， aiming to provide references for further research and clinical practice.
