Active Components and Compound Prescriptions of Glycyrrhizae Radix et Rhizoma in Treatment of Ulcerative Colitis： A Review
10.13422/j.cnki.syfjx.20231313
- VernacularTitle:甘草有效成分及复方治疗溃疡性结肠炎的研究进展
- Author:
Guangmiao GAO
1
;
Lingling YANG
1
;
Xiujuan YANG
1
;
Tingmei YING
1
;
Biqian YANG
1
;
Xiaolong LIAN
2
;
Xiaoyan FU
1
;
Jie LI
1
;
Quhuan MA
1
;
Yi DENG
1
;
Zhijun YANG
1
Author Information
1. College of Pharmacy， Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Qinghai University， Xining 810016，China
- Publication Type:Journal Article
- Keywords:
Glycyrrhizae Radix et Rhizoma;
active ingredients of Glycyrrhizae Radix et Rhizoma;
ulcerative colitis;
compound prescriptions containing Glycyrrhizae Radix et Rhizoma;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(23):264-274
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis （UC） is a chronic recurrent inflammatory bowel disease which primarily affects the colonic mucosa. The UC patients mainly present diarrhea， abdominal pain， tenesmus， and mucous bloody stools， and even malnutrition and systemic symptoms in severe cases， with rising incidence， which has a significant impact on the health and quality of life of patients. The pathogenesis of UC is not clear， and the Western medical therapies include sulfasalazine， glucocorticoids， and immunosuppressants， which， however， have side effects and unsatisfactory effects. Chinese medicine with high safety， mild adverse reactions， and a multi-component， multi-target， and multi-pathway treatment manner has garnering increasing attention. Therefore， finding the Chinese medicine to treat UC has become a hot spot. Glycyrrhizae Radix et Rhizoma is one of the commonly used Chinese herbal medicines， with the effects of tonifying spleen and reinforcing qi， clearing heat and detoxifying， dispelling phlegm and relieving cough， relieving pain， and harmonizing medicines. Glycyrrhizae Radix et Rhizoma mainly contains glycyrrhizic acid， glycyrrhetinic acid， diammonium glycyrrhizinate and other active ingredients. Modern pharmacological studies have shown that Glycyrrhizae Radix et Rhizoma has anti-inflammatory， antioxidant， antimicrobial， and immunomodulatory activities. According to statistics， Glycyrrhizae Radix et Rhizoma is among the top three Chinese herbal medicines for the treatment of UC. The recent years have witnessed progress in the treatment of UC with Glycyrrhizae Radix et Rhizoma and the related prescriptions. The present study summarized the mechanisms underlying the anti-inflammatory， immunomodulatory， intestinal flora-regulating， cell apoptosis-inducing， and oxidative stress-reducing effects of the key chemical constituents （glycyrrhetinic acid， diammonium glycyrrhizinate， polysaccharide， glycyrrhetinic acid， and isoglycyrrhizin） and compound prescriptions of Glycyrrhizae Radix et Rhizoma. The findings provide a solid foundation for further development and clinical application of Glycyrrhizae Radix et Rhizoma.
