Chinese Medicine Regulates mTOR Signaling Pathway to Prevent and Treat Osteoporosis： A Review
10.13422/j.cnki.syfjx.20231314
- VernacularTitle:中药干预mTOR信号通路防治骨质疏松症研究进展
- Author:
Yize WU
1
;
Xingyong LI
2
;
Xiyan LYU
3
;
Baohua YUAN
1
;
Haisheng LIN
1
;
Xiaotao WEI
1
Author Information
1. Gansu University ofl Chinese Medicine， Lanzhou 730000，China
2. Gansu Provincial People 's Hospital， Lanzhou 730000，China
3. Gansu Provincial Hospital of Traditional Chinese Medicine， Lanzhou 730050，China
- Publication Type:Journal Article
- Keywords:
mammalian target of rapamycin （mTOR） signaling pathway;
phosphatidylinositol 3-kinase（PI3K）/protein kinase B（Akt）/mTOR signaling pathway;
adenosine monophosphate（AMP）-activated protein kinase（AMPK）/mTOR signaling pathway;
osteoporosis;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(23):253-263
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis （OP）， a common systemic skeletal disease in the elderly， is characterised by bone loss and bone microstructural degeneration. Its clinical manifestations include increased bone fragility and bone pain. Furthermore， OP increases the risk of fracture due to the high bone fragility， which leads to lifelong disability or death， imposing a heavy economic and psychological burden on the patients and their families. The pathogenesis of OP is extremely complex and associated with a variety of factors such as proliferation and differentiation of osteoblasts， impairment of osteoclast activity and function， and abnormalities in autophagy activation. Recent studies have found that mammalian target of rapamycin （mTOR） signaing pathway is involved in the regulation of bone homeostasis， which can promote bone formation and improve bone metabolism and bone microstructure by regulating osteoblast proliferation and differentiation and osteoclast function and activating cellular autophagy， thus playing a crucial role in the prevention and treatment of OP. The prevention and treatment of OP with Chinese medicine has a long history， clear efficacy， multiple targets of action， low adverse effects， and wide medicine sources. Therefore， this paper briefly describes the role of mTOR signaling pathway in the development of OP by reviewing the latest research reports and summarizes in detail the latest research results on the treatment of OP with Chinese medicine extracts and prescriptions via the mTOR signaling pathway. This review aims to provide a basis for the in-depth research on the relationship between mTOR signaling pathway and OP and the clinical application of traditional Chinese medicine in the prevention and treatment of OP.
