Ferroptosis in Treatment of Liver Fibrosis with Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20231437
- VernacularTitle:铁死亡在中药治疗肝纤维化中的研究进展
- Author:
Lanlan ZHENG
1
;
Cai GUO
1
;
Yanfang HE
1
;
Jiaojiao XIE
1
;
Fen GAO
1
;
Chun YU
1
;
Yanhua MA
1
Author Information
1. First Clinical Medicine College of Gansu University of Chinese Medicine， Lanzhou 730000， China
- Publication Type:Journal Article
- Keywords:
ferroptosis;
Chinese medicine;
liver fibrosis;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(23):235-244
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic fibrosis characterized by various chronic liver injuries can lead to abnormal activation of hepatic stellate cells， unbalanced production and degradation of extracellular matrix proteins， and excessive deposition that destroys the normal structure of the liver. The aggravated liver fibrosis can cause irreversible cirrhosis and hepatocellular carcinoma， becoming a great challenge to the global health. Ferroptosis is a new form of iron-dependent cell death discovered in recent years， which mainly involves abnormal iron metabolism， lipid peroxide accumulation， and weakening of the antioxidant defense system. A number of studies have reported that inducing ferroptosis in hepatic stellate cells or alleviating ferroptosis in the liver can ameliorate liver fibrosis and reduce liver injury. Chinese medicine widely applied in the treatment of chronic liver diseases has demonstrated good safety， wide therapeutic effects， and easy access compared with Western medicine. Therefore， The intervention of hepatic stellate cells or hepatic ferroptosis by Chinese medicine may be a new direction for the prevention and treatment of liver fibrosis in the future. This paper summarized the various regulatory mechanisms of ferroptosis and expounded how ferroptosis affected the progression of liver fibrosis， providing theoretical support for the prevention and treatment of liver fibrosis with Chinese medicine in the future.
