Chinese Medicine Regulates Signaling Pathways Related to Proliferation and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells： A Review
10.13422/j.cnki.syfjx.202202425
- VernacularTitle:中药调控骨髓间充质干细胞增殖及成骨分化相关信号通路的研究进展
- Author:
Haodong YANG
1
;
Xingwen XIE
2
;
Ning LI
1
;
Xin HUANG
3
;
Zhengya SHANG
1
;
Qianning YAO
1
;
Kai LIU
1
Author Information
1. Gansu University of Chinese Medicine, Lanzhou 730000, China
2. Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China
3. Hunan University of Chinese Medicine, Changsha 410000, China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
bone marrow mesenchymal stem cells;
cell proliferation;
osteogenic differentiation;
signaling pathways
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(23):227-234
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow mesenchymal stem cells （BMSCs） are derived from stem cells isolated from bone marrow and have the potential for multidirectional differentiation and self-renewal. Under certain conditions， BMSCs can be induced to differentiate into osteoblast （OB）， chondrocyte， adipocyte， fibroblast， etc. BMSCs play an important role in maintaining the stability of bone structure and balancing bone metabolism. Promoting the proliferation of BMSCs and inducing their differentiation into OB of great significance for the clinical prevention and treatment of osteoporosis， bone defects， fracture healing， and other diseases. Because the proliferation and osteogenic differentiation of BMSCs are complex processes controlled by multiple genes and regulated by multiple signal transduction pathways， traditional Chinese medicine （TCM） happens to have the advantages of multi-bioactive component， multi-target， and multi-pathway synergism， which can affect the proliferation and differentiation of BMSCs through multiple channels and induce the proliferation of BMSCs. The transcription and expression of genes related to osteogenesis can be enhanced to promote the differentiation of BMSCs into OB， so as to achieve the purpose of preventing and treating osteoporosis， bone defects， and other bone diseases. Based on the literature on the intervention of TCM monomers and compounds in the proliferation and osteogenic differentiation of BMSCs， this study reviewed TCM monomers and compounds in promoting the proliferation and osteogenic differentiation of BMSCs by regulating secreted glycoprotein （Wnt）， neurogenic locus notch homolog protein （Notch）， mitogen-activated protein kinase （MAPK）， phosphatidylinositol-3 kinase （PI3K） /protein kinase B （Akt）， bone morphogenetic protein （BMP）/Smad， Janus kinase （JAK）/signal transducer and activator of transcription protein （STAT）， osteoprotegerin （OPG）/receptor activator of nuclear factor-kappa B （RANK）/RANK ligand （RANKL）， and other signaling pathways to provide new ideas for the research and clinical application of Chinese medicine in the prevention and treatment of orthopedic diseases.
