Qianjin Weijingtang in Treatment of Chronic Obstructive Pulmonary Disease： A Review
10.13422/j.cnki.syfjx.20230621
- VernacularTitle:千金苇茎汤治疗慢性阻塞性肺疾病的研究进展
- Author:
Xin PENG
1
;
Yun WANG
1
;
Yunpu QIN
1
;
Yunfan WANG
1
;
Jihong FENG
2
Author Information
1. Tianjin University of Traditional Chinese Medicine（TCM），Tianjin 301617，China
2. The Second Affiliated Hospital of Tianjin University of TCM，Tianjin 300250，China
- Publication Type:Journal Article
- Keywords:
Qianjin Weijingtang;
chronic obstructive pulmonary disease;
clinical study;
mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(23):189-196
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease （COPD） is a chronic heterogeneous airway disease characterized by persistent and progressive airflow restriction， which can be divided into stable COPD and acute exacerbations of COPD （AECOPD）. Its morbidity and mortality remain high， posing a serious threat to human health. Traditional Chinese Medicine （TCM） believes that COPD belongs to the categories of "cough"， "dyspnea syndrome"， "lung distension"， etc. And its basic pathogenesis is intermingled phlegm and stasis with deficiency in origin and excess in superficiality. Qianjin Weijingtang， derived from the Records of Proved Prescriptions， Ancient and Modern （古今录验方）， consists of Phragmitis Caulis， Persicae Semen， Coicis Semen， and Benincasae Semen， with remarkable functions in clearing the lung， resolving phlegm and eliminating blood stasis， and has definite clinical efficacy in treating COPD and its syndromes. At present， in clinical studies， Qianjin Weijingtang has been used to treat COPD with modifications. It can be used alone or in combination with other prescriptions/western medicines to treat stable COPD， AECOPD， COPD complications， and other TCM syndromes of COPD such as phlegm-heat-stagnation obstructing the lung syndrome. It can significantly improve clinical symptoms， lung function， and blood gas indexes， and inhibit inflammatory response. Animal experiments mainly explored the mechanism of COPD from the level of pathological changes. Specifically， the underlying mechanism may be related to regulating T helper 17 （Th17）/regulatory T cells （Treg） balance， up-regulating single immunoglobulin IL-1-related receptor （SIGIRR） for resisting inflammation， up-regulating hyperplasia suppressor gene （HSG） and inhibiting Wnt signaling pathway activation to inhibit airway remodeling. It was found that there were many problems， such as low quality of clinical research， failure in sharing research standards， and the lack of mechanism research. This article systematically reviewed clinical studies of Qianjin Weijingtang in the treatment of COPD and its mechanism based on animal experiments in recent years， and put forward thoughts and suggestions according to the existing problems to provide references for the clinical application and further research on Qianjin Weijingtang.
