Intervention of Traditional Chinese and Western Medicine in NLRP3 Inflammasome-mediated Digestive System Diseases： A Review
10.13422/j.cnki.syfjx.20232191
- VernacularTitle:NLRP3炎症小体介导的消化系统疾病的中西医干预研究进展
- Author:
Guozheng LIU
1
;
Yanyan CHEN
1
;
Shuo YANG
2
;
Yi LIU
1
;
Yanpei ZHAO
1
;
Lijie ZHOU
1
;
Xinyu WANG
1
;
Yangyang SUN
1
;
Yan LI
1
;
Jinjiang DUAN
1
;
Liming CHEN
1
;
Jingdong XIAO
2
Author Information
1. (1.Liaoning University of Traditional Chinese Medicine(TCM),Shenyang 110847,China
2. Liaoning University of TCM Hospital Subsidiary Fourth,Shenyang 110847,China
- Publication Type:Review
- Keywords:
nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 （NLRP3）;
inflammasome;
digestive system;
digestive diseases;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(23):174-188
- CountryChina
- Language:Chinese
-
Abstract:
The aberrant activation of the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 （NLRP3） inflammasome as an essential component of the innate system is implicated in the pathogenesis of several human inflammatory diseases. Studies have confirmed its association with digestive system diseases such as ulcerative colitis， Crohn's disease， and acute pancreatitis， suggesting that the NLRP3 inflammasome plays a role in the initiation and progression of these diseases. Based on the mechanism of NLRP3 inflammasome activation and the pathways that mediate the inflammatory response， this article introduced the relationship between the NLRP3 inflammasome and the pathogenesis of multiple digestive system diseases and the Chinese and western medical therapies. Traditional Chinese medicine （TCM） has demonstrated definite effects on the NLRP3 inflammasome-mediated digestive system diseases. Some single Chinese medicines or TCM prescriptions can treat digestive system diseases by activating or inhibiting NLRP3 inflammasome activation. NLRP3 inflammasome can receive a variety of endogenous and exogenous stimulatory signals， which can initiate， activate， and mediate inflammatory responses. The inflammasome formation and downstream inflammatory cytokines are involved in not only the inflammatory responses but also the development and progression of multiple digestive system diseases. Therefore， the NLRP3 inflammasome can serve as an ideal target for disease treatment. The future rediscovery and in-depth studies of multiple inflammasomes will shed new light on the treatment of multiple digestive system diseases.
