A rare case of multiple pituitary adenomas in an adolescent Cushing disease presenting as a vertebral compression fracture.
10.6065/apem.2017.22.3.197
- Author:
Ji Yeon SONG
1
;
Sue Jean MUN
;
Soon Ki SUNG
;
Jae Yeon HWANG
;
Seung Kug BAIK
;
Jee Yeon KIM
;
Chong Kun CHEON
;
Su Young KIM
;
Yoo Mi KIM
Author Information
1. Department of Pediatrics, Pusan National University Children’s Hospital, Yangsan, Korea. ymk@pusan.ac.kr
- Publication Type:Case Report
- Keywords:
Adolescent;
Cushing disease;
Multiple pituitary adenomas;
Transsphenoidal surgery
- MeSH:
Adolescent*;
Child;
Follow-Up Studies;
Fractures, Compression*;
Headache;
Humans;
Hypertension;
Magnetic Resonance Imaging;
Male;
Pituitary ACTH Hypersecretion*;
Pituitary Neoplasms*;
Weight Gain
- From:Annals of Pediatric Endocrinology & Metabolism
2017;22(3):197-202
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cushing disease in children and adolescents, especially with multiple pituitary adenomas (MPAs), is very rare. We report 17-year-old boy with MPAs. He presented with a vertebral compression fracture, weight gain, short stature, headache, and hypertension. On magnetic resonance imaging (MRI), only a left pituitary microadenoma was found. After surgery, transient clinical improvement was observed but headache and hypertension were observed again after 3 months later. Follow-up MRI showed a newly developed right pituitary microadenoma 6 months after the surgery. The need for careful clinical and radiographic follow-up should be emphasized in the search for potential MPAs in patients with persistent Cushing disease.
