Accuracy Assessment of Five Equations Used for Estimating the Glomerular Filtration Rate in Korean Adults.
10.3343/alm.2017.37.5.371
- Author:
Tae Dong JEONG
1
;
Eun Jung CHO
;
Woochang LEE
;
Sail CHUN
;
Ki Sook HONG
;
Won Ki MIN
Author Information
1. Department of Laboratory Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Accuracy;
Comparison;
Creatinine;
Equation;
Glomerular filtration rate
- MeSH:
Adult*;
Asian Continental Ancestry Group;
Bias (Epidemiology);
Cooperative Behavior;
Creatinine;
Epidemiology;
Glomerular Filtration Rate*;
Humans;
Renal Insufficiency, Chronic
- From:Annals of Laboratory Medicine
2017;37(5):371-380
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: We aimed to assess the performance of the five creatinine-based equations commonly used for estimates of the glomerular filtration rate (eGFR), namely, the creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPIcr), Asian CKD-EPI, revised Lund–Malmö (revised LM), full age spectrum (FAS), and Korean FAS equations, in the Korean population. METHODS: A total of 1,312 patients, aged 20 yr and above who underwent ⁵¹Cr-EDTA GFR measurements (mGFR), were enrolled. The bias (eGFR–mGFR) and precision (root mean square error [RMSE]) were calculated. The accuracy (P30) of four eGFR equations was compared to that of the CKD-EPIcr equation. P30 was defined as the percentage of patients whose eGFR was within±30% of the mGFR. RESULTS: The mean bias (mL·min⁻¹·1.73 m⁻²) of the five eGFR equation was as follows: CKD-EPIcr, -0.6; Asian CKD-EPI, 2.7; revised LM, -6.5; FAS, -2.5; and Korean FAS, -0.2. The bias of the Asian CKD-EPI, revised LM, and FAS equations showed a significant difference from zero (P<0.001). The RMSE values were as follows: CKD-EPIcr, 15.6; Asian CKD-EPI, 15.6; revised LM, 17.9; FAS, 16.3; and Korean FAS, 15.8. There were no significant differences in the P30 except for the Asian CKD-EPI equation: CKD-EPIcr, 76.6%; Asian CKD-EPI, 74.7%; revised LM, 75.8%; FAS, 76.0%; and Korean FAS, 75.8%. CONCLUSIONS: The CKD-EPIcr and Korean FAS equations showed equivalent analytical and clinical performances in the Korean adult population.
