Radioguided Surgery in Insulinoma Using 68Ga Labeled Exendin-4: a Case Report
10.1007/s13139-021-00698-3
- Author:
Subha Shankar DAS
1
;
Parul THAKRAL
;
Divya MANDA
;
Virupakshappa CB
;
Dharmender MALIK
;
Ishita SEN
Author Information
1. Department of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, Haryana 122002, India
- Publication Type:CASE REPORT
- From:Nuclear Medicine and Molecular Imaging
2021;55(5):253-256
- CountryRepublic of Korea
- Language:English
-
Abstract:
Laparoscopic resection of tumor is often performed for benign and small insulinomas, or for those located in the body or tail of the pancreas. The precise preoperative and intraoperative localization of the insulinoma is critical to minimize the surgical intervention. Conventional imaging studies, i.e., MRI, CT, and endoscopic ultrasound have limited sensitivity due to the small size of the insulinomas. Angiography, intraarterial calcium stimulation, and venous sampling are invasive procedures with concomitant risk for complications. Exendin-4 PET/CT scan has shown to be of great value in preoperative localization of insulinomas. In the absence of the traditional gold standard, i.e., intraoperative ultrasound with manual palpation, in laparoscopic surgery, a simple enucleation procedure might not be possible. Gamma probe-assisted surgery is a new method of diagnosis and treatment which allows a small area of tissue to be identified and removed, while a large area of the organ or the system remains unaffected. We present a case of a 34-year-old man with clinical suspicion of insulinoma with negative conventional imaging and successful lesion localization with 68Ga-Exendin-4 PET/CT scan in the pancreatic body, who underwent laparoscopic enucleation of the lesion with the aid of a hand-held gamma detecting probe.
