Does the Incremental Value of 123 I-Metaiodobenzylguanidine SPECT/ CT over Planar Imaging Justify the Increase in Radiation Exposure?
10.1007/s13139-021-00707-5
- Author:
Dorra BEN-SELLEM
1
;
Naima BEN-REJEB
Author Information
1. Université de Tunis El Manar, Faculté de Médecine de Tunis, Laboratoire de Recherche en Biophysique Et Technologies Médicales (LRBTM) ISTMT, Institut Salah AZAIEZ: Service de Médecine Nucléaire, 1006 Tunis, Tunisia
- Publication Type:ORIGINAL ARTICLE
- From:Nuclear Medicine and Molecular Imaging
2021;55(4):173-180
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:Planar scintigraphy with 123 I-radiolabeled metaiodobenzylguanidine (123 I-mIBG) is an important imaging modality to evaluate neuroblastoma. In recent years, Single Photon Emission Computed Tomography combined with Computed Tomography (SPECT/CT) has revolutionized nuclear medicine. Nevertheless, the addition of the CT has increased the patients’ irradiation. We aimed to evaluate the incremental benefits of 123 I-mIBG SPECT/CT over conventional planar imaging and to estimate the relative increase of radiation dose.
Methods:We retrospectively evaluated the added value of 56 SPECT/CT performed in 40 children in terms of better characterization of the lesion and its locoregional extension, better lymph node staging, detection of new lesions, and elimination of false positives by a paired comparison between the planar images and the SPECT/CT ones. Then, we calculated the percentage contribution of the additional radiation of the CT in this hybrid imagery.
Results:In 88% (49 out of 56) of the examinations, SPECT/CT provided additional information, which was crucial in 20% of the cases. It allowed a better characterization of the lesion and its locoregional extension in 44 cases, a better lymph node staging in 28 cases, the detection of 33 new lesions, and the elimination of 9 false positives. The CT effective dose was significantly lower than the SPECT one. The average additional radiation exposure due to CT was 12% (4–23%).
Conclusion:123 I-mIBG SPECT/CT has an undeniable added value that improves planar imaging interpretation and impacts patient management. These potential benefits would justify the low additional radiation induced by the CT.
