Preclinical Voxel-Based Dosimetry in Theranostics: a Review
10.1007/s13139-020-00640-z
- Author:
Arun GUPTA
1
;
Min Sun LEE
;
Joong Hyun KIM
;
Dong Soo LEE
;
Jae Sung LEE
Author Information
1. Department of Radiology & Imaging, B.P. Koirala Institute of Health Sciences, Dharan, Nepal
- Publication Type:REVIEW
- From:Nuclear Medicine and Molecular Imaging
2020;54(2):86-97
- CountryRepublic of Korea
- Language:English
-
Abstract:
Due to the increasing use of preclinical targeted radionuclide therapy (TRT) studies for the development of novel theranosticagents, several studies have been performed to accurately estimate absorbed doses to mice at the voxel level using referencemouse phantoms and Monte Carlo (MC) simulations. Accurate dosimetry is important in preclinical theranostics to interpretradiobiological dose-response relationships and to translate results for clinical use. Direct MC (DMC) simulation is believed toproduce more realistic voxel-level dose distribution with high precision because tissue heterogeneities and nonuniform sourcedistributions in patients or animals are considered. Although MC simulation is considered to be an accurate method for voxelbasedabsorbed dose calculations, it is time-consuming, computationally demanding, and often impractical in daily practice. Inthis review, we focus on the current status of voxel-based dosimetry methods applied in preclinical theranostics and discuss theneed for accurate and fast voxel-based dosimetry methods for pretherapy absorbed dose calculations to optimize the dosecomputation time in preclinical TRT.
