Research on Syndrome and Treatment Rules of Famous Doctors in Treating Ulcerative Colitis Based on Data Mining
10.13288/j.11-2166/r.2023.21.013
- VernacularTitle:基于数据挖掘的名医名家治疗溃疡性结肠炎辨证治疗规律研究
- Author:
Yujie WU
1
;
Ting WANG
2
;
Peixuan ZHU
1
;
Yonghuang YAN
1
;
Han YANG
3
;
Wenting ZHANG
1
;
Fang YAN
4
;
Shiqing QIAO
3
;
Cai ZHANG
5
;
Zeqi SU
5
Author Information
1. School of Traditional Chinese Medicine， Beijing University of Chinese Medicine，Beijing，100029
2. School of Chinese Meteria Medica， Beijing University of Chinese Medicine
3. School of Life Sciences，Beijing University of Chinese Medicine
4. Dongfang Hospital，Beijing University of Chinese Medicine
5. Beijing Research Institute of Chinese Medicine， Beijing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
ulcerative colitis;
Master of Traditional Chinese Medicine;
National Famous Chinese Medicine Practitioners;
data mining;
characteristics of syndrome;
characteristics of medication;
experience of famous doctors
- From:
Journal of Traditional Chinese Medicine
2023;64(21):2241-2247
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo systematically review the clinical experience of four sessions of Masters of Traditional Chinese Medicine and two sessions of National Famous Chinese Medicine Practitioners in treating ulcerative colitis （UC）. Data mining and analysis were conducted to clarify the diagnosis and treatment ideas and characteristics of prescription used by these famous doctors in treating UC. MethodsRelevant literature on the treatment of UC by renowned doctors was retrieved from the establishment of the database until March 31， 2023. The literature was collected from databases such as China National Knowledge Infrastructure （CNKI）， Wanfang Data Knowledge Service Platform， Chinese Science and Technology Periodicals Database， and China Biomedical Literature Database. The data mining techniques including frequency analysis， association rules， and cluster analysis were conducted using the Ancient and Modern Medical Case Cloud Platform V2.3.5. ResultsA total of 157 literatures were included in this study， including 115 clinical case data. The study found that UC can be categorized into 14 types of syndrome patterns for treatment， including large intestine dampness-heat syndrome （75，65.22%）， syndrome of dampness stagnancy due to spleen deficiency （23， 20.00%）， spleen-kidney yang deficiency syndrome （21， 18.26%）. The main affected organs were the spleen （85， 73.91%） and large intestine （75， 65.22%）， and they were closely related to liver （24， 20.87%） and the kidney （21， 18.26%）. The predominant pathogenic factors were dampness （83， 72.17%） ， heat （80， 69.57%） and qi deficiency （65， 56.52%）. The treatment involved 30 kinds of treatment methods， including heat-clearing and dampness-draining method （75， 65.22%）， pleen-tonifying and qi-boosting method （25，21.74%） and spleen-invigorating and dampness-transforming method （23， 20.00%）. The medication involved 187 ingredients， with the most commonly used being heat-clearing herbs （37， 19.79%） and tonifying herbs （27， 14.44%）. The tastes of the herbs were mostly sweet （85， 45.45%） ， bitter （80， 42.78%） ， and pungent （71， 37.97%）. The association rules revealed 16 high-frequency combinations mainly composed of Huanglian （黄连）， Baishao （白芍） and Gancao （甘草） along with Baizhu （白术）， Fuling （茯苓）， Muxiang （木香） and Danggui （当归）. ConclusionFamous doctors are skilled in diagnosing and treating UC based on the differentiation of the zang-fu organs and qi-blood. The key pathological mechanism is “spleen deficiency as the root， and large intestine damp-heat as the manifestation”. The core treatment approach is “heat-clearing， spleen-tonifying， and dampness-draining”， with the inclusion of “regulating qi and blood， and balancing cold and heat”.
