Thoughts and Analysis on Regulating Tumor Pre-Metastatic Niche by Regulating Qi and Detoxifying
10.13288/j.11-2166/r.2023.20.006
- VernacularTitle:调气解毒法调控恶性肿瘤转移前生态位的思路与探析
- Author:
Juan LI
1
;
Bolun SHI
1
;
Yue LI
1
;
Rui LIU
1
;
Baojin HUA
1
Author Information
1. Guang'anmen Hospital，China Academy of Chinese Medical Sciences，Beijing 100053
- Publication Type:Journal Article
- Keywords:
malignant tumor;
tumor metastasis;
pre-metastatic niche;
qi regulation and detoxification
- From:
Journal of Traditional Chinese Medicine
2023;64(20):2077-2081
- CountryChina
- Language:Chinese
-
Abstract:
Based on the concept of “imbalance of qi movement with the latent cancer toxin”， it is believed that the development process of tumor pre-metastatic niche （PMN） could be summarized as tumor derived secretory factors， exosomes and other “cancer toxin”， which latent in the body， were diffusion-prone by means of meridians and membrane-sources. Besides， the latent toxin induced the imbalance of qi movement， especially the distant weakest qi， and the local sweat pore and collateral vessels were blocked， which resulted in phlegm and blood stasis， and the cross-aggregation of poison. We also proposed therapeutic principles of PMN as first regulating qi and then clearing and expelling toxin， and tried to discuss the theoretical model of traditional Chinese medicine for PMN based on the theory of qi regulation and detoxification， aimed at providing ideas for the future theory construction of traditional Chinese medicine prevention and treatment for malignant tumor metastasis.
