Protective effect of nimodipine and mannitol on brain injury of cerebral ischemia-reperfusion in rats
- VernacularTitle:尼莫地平和甘露醇对急性脑缺血再灌注大鼠的影响
- Author:
Chunhua PIAO
;
Shurong JI
;
Jianpeng XU
- Publication Type:Journal Article
- Keywords:
ischemia-reperfusion, combined medication, nimodipine, mannitol, synergistic action
- From:
Chinese Journal of Rehabilitation Theory and Practice
2001;7(4):153-154
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study protective effect of combined medication with nimodipine and mannitol on injury of cerebral ischemia-reperfusion.MethodsA model of cerebral ischemia-reperfusion injury was performed by clipping bilateral common carotid arteries and vagi, then by releasing them to reperfuse blood into ischmic brain of rats. Changes of SOD, MDA and excitatory amino acids( glutamic acid, Glu) in serum were detected after cerebral ischmia-repefusion in different groups. At the same time pathologic study was performed. ResultsTreatment with nimodipine and mannitol is significantly effective than single medication. ConclusionsCombined medication with nimodipine and mannitol protects brain tissue from cerebral ischemia-reperfusion by synergistic action.
