Effect of antidepressants on thyroid hormone level in adolescent depression with suicidal ideation
10.19428/j.cnki.sjpm.2023.22732
- VernacularTitle:抗抑郁药治疗青少年抑郁症伴自杀意念的患者的甲状腺激素水平
- Author:
Jiali ZHANG
1
;
Xiaoquan WANG
2
;
Hui XU
2
;
Zusen WANG
2
;
Lianzi WANG
2
;
Fangfang CHEN
2
;
Tao YANG
2
Author Information
1. Wannan Medical College, Wuhu, Anhui 241000, China
2. The Fourth People's Hospital of Wuhu City, Wuhu, Anhui 241000, China
- Publication Type:Journal Article
- Keywords:
teenager;
depression;
suicidal ideation;
thyroid hormone;
antidepressant
- From:
Shanghai Journal of Preventive Medicine
2023;35(8):786-790
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo compare the differences in thyroid hormone levels between adolescents with and without suicidal ideation， and to explore the association between thyroid hormone/suicidal ideation and the antidepressant treatment. MethodsA total of 100 patients were divided into non-suicidal ideation group and suicidal ideation group according to the SIOSS. The levels of thyroid-stimulating hormone （TSH）， triiodothyronine （T3）， thyroxine （T4）， free triiodothyronine （FT3） and free thyroxine （FT4） were compared between the two groups as well as their changes after 6 weeks of antidepressant treatment. ResultsThe levels of FT3， FT4 and T4 in the non-suicidal ideation group were higher than those in the suicidal ideation group. After 6 weeks of antidepressant treatment， the levels of FT3， FT4 and T4 in the suicide ideation group were higher than those before the treatment. The FT3 level in the male non-suicidal ideation group was higher than that in the suicidal ideation group. The levels of FT4 and T4 in the female non-suicidal ideation group were higher than those in the suicidal ideation group （all P<0.05） ConclusionThere are differences in thyroid hormone levels between adolescents with and without suicidal ideation （both with first-episode depression）， and patients with suicidal ideation have significant changes after treatment with antidepressants.
