Hemocompatibility of bioprosthetic heart valve materials respectively based on glutaraldehyde and non-glutaraldehyde treatment
- VernacularTitle:基于戊二醛和非戊二醛处理体系制备的生物瓣膜材料的血液相容性评估
- Author:
Xiaoxiao WEN
1
;
Wenzhi PAN
2
;
Kun ZHANG
1
;
Kongrong PAN
1
;
Daxin ZHOU
2
;
Junbo GE
2
Author Information
1. Peijia Medical Limited, Suzhou, 215000, Jiangsu, P. R. China
2. Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese
- Publication Type:Journal Article
- Keywords:
Bioprosthetic heart valve;
bovine pericardium;
glutaraldehyde;
carbodiimide;
hemocompatibility
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2023;30(09):1323-1328
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the hemocompatibility of bioprosthetic heart valve materials respectively based on glutaraldehyde and non-glutaraldehyde treatment. Methods Fresh bovine pericardium was treated with glutaraldehyde or non-glutaraldehyde after adipose tissue was removed. To evaluate the hemocompatibility of the two bioprosthetic heart valve materials, hemolysis test, in vitro fibrinogen adsorption experiment, platelet adhesion experiment, thrombin-antithrombin complex (TAT) test, complement activation assay and ex vivo circulation experiment were performed. Results The hemolysis test results demonstrated that both of the materials showed hemolytic rates lower than 5%. The results of TAT test and complement activation assay showed no statistical differences among the two materials and the blank control group. Compared to the bioprosthetic heart valve materials with glutaraldehyde-based treatment, the materials with non-glutaraldehyde-based treatment showed significantly decreased fibrinogen adsorption, platelet adhesion and thrombosis. Conclusion Compared to the bioprosthetic heart valve materials with glutaraldehyde-based treatment, the materials with non-glutaraldehyde-based treatment show better hemocompatibility.
