Study on change of aminoacid content in the brain of newborn rabbits with bilirubin encephalopathy
- VernacularTitle:胆红素脑病仔兔脑组织氨基酸含量的研究
- Author:
Lin LI
;
Xiaojie LI
;
Zhimei JIANG
;
Jie LV
- Publication Type:Journal Article
- Keywords:
bilirubin encephalopathy, neurotransmitter, non neurotransmitter
- From:
Chinese Journal of Rehabilitation Theory and Practice
2001;7(3):118-119
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study change of aminoacid content in the brain of newborn rabbits with bilirubin encephalopathy. MethodsNewborn rabbits (3-5 days after birth) with bilirubin encephalopathy were induced by administration intra peritoneally with bilirubin (200mg/kg). Aminoacid content in brain were analysed by Hitachi 835 50 type aminoacid analysis instrument.ResultsThe content of glutamate and aspartate in brain tissue with bilirubin encephopathy decrease; GABA, alanine, tyrosine, valine and pheny lalanine increase. ConclusionsThe change of content of neurotransmitters in brain indicates that excitotoxicity of EAAs may contribute to the bilirubin encephalopathy. The increase of non neurotransmitters level proves that bilirubin may inhibit the biologic composition of protein in brain.
