Effects of midazolam combined with propofol on recovery of patients with laparoscopic cholecystectomy
10.12206/j.issn.2097-2024.202206087
- VernacularTitle:咪达唑仑联合丙泊酚麻醉对腹腔镜胆囊切除术后患者恢复的影响
- Author:
Tingwei SHI
1
;
Hui XIAO
1
;
Maoli LIU
1
;
Jie ZHOU
1
;
Yulin ZHU
1
Author Information
1. Department of Anesthesiology, the First People’s Hospital of Longquan District, Chengdu (West China Longquan Hospital, Sichuan University), Chengdu 610100, China.
- Keywords:
Midazolam;
Propofol;
Laparoscopic cholecystectomy;
Stress response;
Cognitive function;
Sleep quality
- From:
Journal of Pharmaceutical Practice
2023;41(10):638-642
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect midazolam combination with propofol on postoperative recovery in patients undergoing laparoscopic cholecystectomy. Methods A total of 162 patients who were admitted to the hospital for laparoscopic cholecystectomy from April 2019 to January 2021 were selected. According to different anesthesia methods, they were divided into control group (midazolam anesthesia) and observation group (midazolam combined with propofol anesthesia), with 81 cases in each group. The stress index levels before and after operation, MoCA scores before operation (T0), 24 h after operation (T1) and 48 h after operation (T2), sleep quality at T0, the first day after operation (T3) and the second day after operation (T4), the perioperative recovery were compared between the two groups. Results The levels of Cor and NE, the recovery time of eyes opening, extubation, orientation, and the incidence of adverse reactions in the observation group were lower than those in the control group (P<0.05). Observation group MMSE score when T1, T2, T3, T4 sleep quality score were higher than control group (P<0.05). Conclusion Midazolam combined with propofol was safe and had good postoperative recovery in patients undergoing laparoscopic cholecystectomy.
