Analysis of association between severity of capecitabine-induced hand-foot syndrome and inflammatory factors
10.12206/j.issn.2097-2024.202108129
- VernacularTitle:卡培他滨致手足综合征严重程度与血浆中炎症因子含量的分析
- Author:
Yanping LIU
1
,
2
;
Zhipeng WANG
3
;
Lili CUI
1
,
2
;
Fengjing XU
3
;
Mengwei ZHANG
1
,
2
;
Shouhong GAO
3
Author Information
1. Department of Pharmacy, Changzheng Hospital, Naval Medical University, Shanghai 200003, China
2. Bioengineering Research Institute of Yichun University, Yichun 336000, China.
3. Department of Pharmacy, Changzheng Hospital, Naval Medical University, Shanghai 200003, China.
- Keywords:
colorectal cancer;
capecitabine;
hand-foot syndrome;
inflammatory factors
- From:
Journal of Pharmaceutical Practice
2023;41(10):634-637
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between plasma inflammatory factors [IL-1β, IL-6, IL-10, IL-12, IL-17, IL-23, TNF-α, TGF-β, IFN-γ, C-reactive protein (CPR) CCL-5] and hand-foot syndrome in colorectal cancer patients after taking capecitabine. Methods 35 colorectal cancer patients treated with capecitabine were collected and the degree of severity was divided according to the hand-foot syndrome grading diagnostic criteria. The concentrations of inflammatory factors in plasma were determined by ELISA kits. Results The standard curve of all inflammatory cytokines were linear (r>0.9900), and plasma concentrations of inflammatory cytokines in patients with colorectal cancer were determined. The concentration of TNF-α changed obviously, which had reference value. Conclusion The concentrations of different inflammatory factors were different and the concentration of TNF-α was closely correlated with the severity of hand-foot syndrome.
