Analysis of association between severity of capecitabine-induced hand-foot syndrome and inflammatory factors
10.12206/j.issn.2097-2024.202108129
- VernacularTitle:卡培他滨致手足综合征严重程度与血浆中炎症因子含量的分析
- Author:
Yanping LIU
1
;
Zhipeng WANG
2
;
Lili CUI
1
;
Fengjing XU
2
;
Mengwei ZHANG
1
;
Shouhong GAO
2
Author Information
1. Department of Pharmacy, Changzheng Hospital, Naval Medical University, Shanghai 200003, China;Bioengineering Research Institute of Yichun University, Yichun 336000, China.
2. Department of Pharmacy, Changzheng Hospital, Naval Medical University, Shanghai 200003, China.
- Keywords:
colorectal cancer;
capecitabine;
hand-foot syndrome;
inflammatory factors
- From:
Journal of Pharmaceutical Practice
2023;41(10):634-637
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between plasma inflammatory factors [IL-1β, IL-6, IL-10, IL-12, IL-17, IL-23, TNF-α, TGF-β, IFN-γ, C-reactive protein (CPR) CCL-5] and hand-foot syndrome in colorectal cancer patients after taking capecitabine. Methods 35 colorectal cancer patients treated with capecitabine were collected and the degree of severity was divided according to the hand-foot syndrome grading diagnostic criteria. The concentrations of inflammatory factors in plasma were determined by ELISA kits. Results The standard curve of all inflammatory cytokines were linear (r>0.9900), and plasma concentrations of inflammatory cytokines in patients with colorectal cancer were determined. The concentration of TNF-α changed obviously, which had reference value. Conclusion The concentrations of different inflammatory factors were different and the concentration of TNF-α was closely correlated with the severity of hand-foot syndrome.
