Effect of pharmacogenetic polymorphism on the antiplatelet aggregation effect of ticagrelor
10.12206/j.issn.2097-2024.202207087
- VernacularTitle:药物基因多态性对替格瑞洛抗血小板聚集效果的影响
- Author:
Xiaoyun XIE
1
;
Aiwen HUANG
1
;
Li LI
2
;
Yan JIANG
1
;
Jiasong CAI
1
Author Information
1. Department of Clinical Medicine, No. 900 Hospital of Joint Logistics Support Force of the PLA, Fuzhou 350025, China.
2. Tengzhou Central People's Hospital, Tengzhou 277599, China.
- Keywords:
acute coronary syndrome;
ticagrelor;
pharmacogenetic polymorphisms;
antiplatelet aggregation
- From:
Journal of Pharmaceutical Practice
2023;41(10):629-633
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop a pharmacogenomics study of ticagrelor in patients with acute coronary syndrome (ACS), identify the genetic factors that can predict individual differences in antiplatelet aggregation effects of ticagrelor, and provide a reference for the development of individualized regimens for ticagrelor. Methods 75 ACS patients of Chinese Han in a hospital in Fujian province in 2018 who met the entry criteria were recruited. The patient was given the tests for platelet function test, platelet aggregation rate and DNA detection. The whole exon sequencing method (WES) was used to detect the single nucleotide polymorphisms of SLO1B1, UGT2B7, P2Y12, PEAR1, ITGA2B and ITGB3. At the same time, the general clinical data of the patients were collected and recorded. The correlation between antiplatelet aggregation effects of ticagrelor and pharmacogenetic polymorphism was analyzed by one-way analysis of variance, multiple linear regression analysis and binary logistic regression analysis. Results One-way analysis of variance showed that SLCO1B1 rs2306283 mutant allele G could affect the antiplatelet aggregation effect of ticagrelor, the average platelet aggregation rate of patients carrying at least one allele G (AG+GG type) was significantly lower than that of wild homozygotes AA patients (8.07%±6.17% vs 13.88%±6.39%, P≤0.05). However, multivariate regression analysis after adjusting for confounding factors showed that SLCO1B1 rs2306283 mutant allele G was not an independent variable affecting the antiplatelet effects of ticagrelor (P>0.05). Conclusion Single nucleotide polymorphisms of genes related to ticagrelor transport receptors, targets, and platelet membrane receptors (including SLO1B1, UGT2B7, P2Y12, PEAR1, ITGA2B, ITGB3) in ACS patients of Han Chinese in Fujian province will not significantly affect the antiplatelet aggregation effect of ticagrelor, which provides a new treatment option for patients with genetic defects who are not suitable for clopidogrel.
