Research progress of Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 signaling pathway regulated retinal oxidative stress
10.3980/j.issn.1672-5123.2023.11.14
- VernacularTitle:KEAP1-NRF2信号通路调控视网膜氧化应激的研究进展
- Author:
Zhi-Ming GU
1
,
2
,
3
,
4
;
Wei-Qi ZHONG
1
,
2
,
3
,
4
;
Chang-Jun LAN
1
,
2
,
3
,
4
;
Xuan LIAO
1
,
2
,
3
,
4
Author Information
1. Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
2. Medical School of Ophthalmology &
3. #x0026
4. Optometry, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
- Publication Type:Journal Article
- Keywords:
oxidative stress;
Kelch-like ECH-associated protein 1- nuclear factor erythroid 2 related factor 2 signaling pathway(KEAP1-NRF2 signaling pathway);
retina;
mechanism
- From:
International Eye Science
2023;23(11):1840-1843
- CountryChina
- Language:Chinese
-
Abstract:
Oxidative stress(OS)is a major reason for body damage. Studies have shown that a variety of factors, such as ischemia and hypoxia, excessive light and hyperglycemia can cause the increase of reactive oxygen species and free radicals in the retina, thus inducing OS, damaging retina and affecting the normal visual function. Kelch-like ECH-associated protein 1(KEAP1)and nuclear factor erythroid 2 related factor 2(NRF2), which together constitute the main antioxidant stress signaling pathway in the body, play an antioxidant role by regulating retinal energy metabolism and cell proliferation, apoptosis and autophagy through various ways, so as to reduce retinal damage caused by OS. In this paper, the role and mechanism of the KEAP1-NRF2 signaling pathway regulation of OS in the retinal are briefly reviewed, aiming to provide ideas for subsequent research.
