Traditional Chinese Medicine Targets mTOR Signaling Pathway for Treatment of Diabetic Kidney Disease： A Review
10.13422/j.cnki.syfjx.20231242
- VernacularTitle:中医药靶向mTOR信号通路治疗糖尿病肾病的研究进展
- Author:
Wei ZHANG
1
;
Rong ZHOU
1
;
Kaixuan DONG
1
;
Xi CHEN
1
;
Xiaoyong YU
2
Author Information
1. First Clinical School， Shaanxi University of Chinese Medicine， Xianyang 712046， China
2. Shaanxi Provincial Hospital of Chinese Medicine， Xi'an 710003， China
- Publication Type:Journal Article
- Keywords:
diabetic kidney disease;
mammalian target of rapamycin （mTOR）;
Chinese medicine;
signaling pathway;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(22):223-230
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease （DKD）， a chronic kidney disease with unique pathological structural and functional alterations in the kidney， is a common complication of diabetes mellitus （DM）. The majority of researchers believe that the occurrence of this disease is associated with glucose metabolism disorders， oxidative stress， inflammation， endoplasmic reticulum stress， autophagy， and disorders of lipid metabolism and exosome release. The mammalian target of rapamycin （mTOR） signaling pathway， which can maintain glomerular podocyte homeostasis and participate in autophagy， renal fibrosis， oxidative stress， lipid metabolism disorders， and inflammatory response in DKD， has been discovered to play a key role in DKD. Therefore， it has emerged as a novel target for the treatment of DKD. Studies have demonstrated that traditional Chinese medicine can prevent the renal damage in DKD by regulating the mTOR signaling pathway to delay the disease progression and improve the prognosis and the quality of life of the patients. This article summarizes the structure and role of the mTOR signaling pathway in DKD and briefs the research progress in the prevention and treatment of DKD via this signaling pathway by the active components， extracts， and compound prescriptions of Chinese medicines， aiming to present new ideas and approaches for the clinical treatment of DKD with traditional Chinese medicine.
