Chinese Medicine Intervenes in NLRP3 Inflammasome in Treatment of Bone and Joint Diseases： A Review
10.13422/j.cnki.syfjx.20230508
- VernacularTitle:中药干预NLRP3炎症小体治疗骨关节相关疾病研究进展
- Author:
Tuanzhuang ZHANG
1
;
Yuan SONG
2
;
Zhijun HE
2
;
Tao LIU
2
;
Xiyan LYU
2
;
Xiaotao WEI
1
;
Jiaxuan SHEN
1
;
Xudong LIANG
1
;
Keyu ZHU
1
;
Jing QIAO
1
Author Information
1. Gansu University of Chinese Medicine，Lanzhou 730000，China
2. Gansu Provincial Hospital of Traditional Chinese Medicine，Lanzhou 730000，China
- Publication Type:Journal Article
- Keywords:
NOD-like receptor family， pyrin domain-containing protein 3 （NLRP3） inflammasome;
Chinese medicine;
osteoporosis;
osteoarthritis;
gouty arthritis;
rheumatoid arthritis;
intervertebral disc degeneration
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(22):193-203
- CountryChina
- Language:Chinese
-
Abstract:
The prevalence of osteoporosis， osteoarthritis， gouty arthritis， rheumatoid arthritis， and intervertebral disc degeneration is increasing year by year with the growing number of elderly people， and the common clinical manifestations of these diseases include severe pain in different areas， which seriously affects the daily life of the patients. Therefore， how to relieve the pain and reduce the prevalence of bone and joint diseases and improve the quality of life of the patients is a hot spot in the medical field. Studies have confirmed that NOD-like receptor family， pyrin domain-containing protein 3 （NLRP3） inflammasomes， as pattern recognition receptors， are involved in the inflammation， chondrocyte proliferation， osteoblast and osteoclast differentiation， intervertebral disc cell inflammation and scorching， extracellular matrix degradation and apoptosis， mitochondrial dysfunction， endoplasmic reticulum stress， and reactive oxygen species damage， demonstrating close link with the development of bone and joint diseases. Chinese medicine has a long history and demonstrates remarkable therapeutic effects in the treatment of bone and joint diseases. It can mitigate the pathological changes of bone and joint diseases by inhibiting NLRP3 inflammasomes to alleviate the pain， playing a role in preventing and treating these diseases. Therefore， this paper briefly describes the relationship between NLRP3 inflammasomes and the development of bone and joint diseases by reviewing the latest research progress at home and abroad. We summarize the latest studies about the active components， extracts， and compound prescriptions of Chinese medicines in the treatment of bone and joint diseases via regulating NLRP3 inflammasomes. This review is expected to offer new insights into the in-depth research on the pathogenesis and drug treatment of bone and joint diseases and provide a basis for the clinical application of Chinese medicine in the prevention and treatment of such diseases.
