Fitting Degrees of Cathartic Colon Animal Models with Disease Characteristics of Western Medicine and Syndrome Characteristics of Traditional Chinese Medicine
10.13422/j.cnki.syfjx.20230819
- VernacularTitle:基于中西医病证特点的泻剂结肠动物模型的临床吻合度分析
- Author:
Youcheng HE
1
;
Fengru JIANG
1
;
Yan ZHOU
1
;
Jianan QIAN
1
;
Jun LIU
1
;
Lu HANG
1
;
Chunyu ZHOU
1
;
Sihan LI
2
;
Minghan HUANG
3
;
Jianye YUAN
1
Author Information
1. Institute of Digestive Diseases， Longhua Hospital， Shanghai University of Traditional Chinese Medicine（TCM）， Shanghai 200032， China
2. Johns Hopkins University， Baltimore 21218， USA
3. The Second People's Hospital Affiliated to Fujian University of TCM， Fuzhou 350003， China
- Publication Type:Journal Article
- Keywords:
cathartic colon;
laxative-dependent constipation;
animal model;
fitting degree with clinical characteristics;
characteristics of diseases of western medicine and syndromes of traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(22):146-154
- CountryChina
- Language:Chinese
-
Abstract:
Cathartic colon （CC） is a common and refractory digestive system disease， with the pathogenesis not fully clarified. The effective therapies other than laxatives and surgery remain to be developed for CC. Therefore， establishing the CC animal models that fit the disease characteristics of western medicine and syndrome characteristics of traditional Chinese medicine （TCM） is an important link to promote the research on this disease. The fitting degree of animal models with the latest Chinese and western medical diagnostic criteria is an indicator to assess the effectiveness of the animal models in simulating the disease characteristics of western medicine and syndrome characteristics of TCM. The literature review showed that the model animals， drugs and their dosage forms， doses， administration methods， and modeling period of CC varied in different studies， and the available CC animal models presented different fitting degrees with the disease characteristics of western medicine and syndrome characteristics of TCM. Rats were the preferred animals for the modeling of CC. Rhei Radix et Rhizoma preparations were commonly used for model inducing， which， however， may cause water electrolyte disorders， decreased immunity， and even death of animals at the late stage of modeling. The animals were modeled by gradually increasing the starting dose， while the starting dose and increasing dose varied. The maintenance dose was determined based on 50% of the animals having loose stools， and the end for a cycle was determined as the time when loose stools disappeared in 80% of animals. The modeling always lasted for 2-3 cycles， approximately 2-4 months. The CC models established with Rhei Radix et Rhizoma granules and rhein had high fitting degrees with the disease and syndrome characteristics. In addition， the CC animal models of TCM syndromes were still in the exploration stage. There were only the animal models of four TCM syndromes： liver depression and spleen deficiency， both Qi and Yin deficiency， Qi stagnation and blood stasis， and spleen and kidney deficiency. Efforts should be made to establish the animal models that meet the characteristics of disease of western medicine and syndromes of TCM， so as to facilitate the research on CC mechanism and drug development.
