Application and Modification of RT-LAMP for Rapid Detection of SARS-CoV-2 Viral Genome
https://doi.org/10.47836/mjmhs.19.2.40
- Author:
Adibah Che Mohamad Nor
1
;
Zainiharyati Mohd Zain
2
;
Mohd Shihabuddin Ahmad Noorden
1
Author Information
1. Brain Laboratory, Faculty of Pharmacy, Universiti Teknologi Mara (UiTM) Puncak Alam Campus,42300 Bandar Puncak Alam Selangor, Malaysia
2. Faculty of Applied Science, Universiti Teknologi Mara (UiTM) Shah Alam Campus, 40450 Shah Alam Selangor, Malaysia
- Publication Type:Review
- Keywords:
RT-LAMP;
RT-PCR;
COVID-19;
SARS-CoV-2
- From:Malaysian Journal of Medicine and Health Sciences
2023;19(No.2):286-292
- CountryMalaysia
- Language:English
-
Abstract:
COVID-19 outbreak caused by the newly discovered SARS-CoV-2 has become a major public health threat around
the world and has create a tremendous effect on the global economy. Hence, there is a high demand for rapid and
accurate diagnosis to contain the spread of the disease. The Reverse-Transcription Polymerase Chain Reaction (RTPCR), the current standard for diagnosis of COVID-19 however possesses certain drawbacks that limits its application
to meet the high demand of the continually increasing COVID-19 cases. Conversely, Loop-Mediated Isothermal
Amplification (LAMP) is another nucleic acid amplification method that shows a great potential as an alternative
tool in rapid diagnosis of COVID-19 due to its simplicity and rapidity. This review summarized the recent published
research articles related to the application and modification of RT-LAMP assay for the rapid detection of COVID-19
in comparison with other available diagnostic methods.
- Full text:11.2023my1490.pdf
