Anti-Obesity Effect of Methanolic Extracts of Local Punica granatum in High-Fat Diet-Induced Obese Rats
https://doi.org/10.47836/mjmhs.19.2.33
- Author:
Nuruljannah Alhany Abdul Halim
1
;
CF Karim
2
;
Imtiaz K. Mohammed
3
;
Ismail Rozila
4
;
Mahani Mahadi
4
;
Zauyah Yusuf
4
;
Shazreen Shaharuddin
5
;
Shamima Abdul Rahman
1
Author Information
1. Pharmacology Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Cyberjaya, Persiaran Bestari, Cyber 11, 63000 Cyberjaya, Selangor, Malaysia
2. Pharmacology, Faculty of Medicine, University of Cyberjaya, Persiaran Bestari, Cyber 11, 63000 Cyberjaya, Selangor, Malaysia
3. Pharmaceutical Chemistry Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Cyberjaya, Persiaran Bestari, Cyber 11, 63000 Cyberjaya, Selangor, Malaysia
4. Basic Sciences Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Cyberjaya, Persiaran Bestari, Cyber 11, 63000 Cyberjaya, Selangor, Malaysia
5. Department Physiology, Faculty of Medicine and Health Defence, National Defence University of Malaysia, Kem Sungai Besi, 57000 Kuala Lumpur, Malaysia
- Publication Type:Journal Article
- Keywords:
Anti-obesity, Punica granatum, Lipid profile, Glucose level
- From:Malaysian Journal of Medicine and Health Sciences
2023;19(No.2):228-235
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Obesity has been linked to coronary artery disease, type II diabetes, metabolic syndrome, stroke, and
cancer. Pomegranate (Punica granatum; PG) has been used extensively in folk medicine for several therapeutic purposes. The goal of this study is to investigate the anti-obesity effect of PG peel and pulp methanolic extracts in highfat diet (HFD)-induced Sprague-Dawley rats. Methods: The animals were separated into 7 groups namely Normal
control group (normal diet); HFD-induced only as negative control group, and positive control group (HFD-induced
+ orlistat); treatment group included HFD-induced + peel 125 mg/kg, HFD-induced +peel 250 mg/kg, HFD-induced
+ pulp 125 mg/kg and HFD-induced + pulp 250 mg/kg. Results: It was observed that methanolic extract of peel and
pulp PG 250 mg/kg showed low increment of body weight with a reduction in weight of liver, visceral fat, and subcutaneous fat. Compared to the negative control group, total cholesterol, triglyceride, and low-density lipoprotein
levels were shown to be lowered for PG peel and pulp groups also showed higher values in high-density lipoprotein.
Conclusion: PG reduced obesity-related markers in blood, liver, and adipose tissue and inhibited obesity caused by
a high-fat diet probably because of its antioxidant properties.
- Full text:11.2023my1483.pdf
