Common problems and considerations in challenge tests of different animal models of SARS-CoV-2 vaccine
10.13200/j.cnki.cjb.003907
- VernacularTitle:SARS-CoV-2疫苗不同动物模型攻毒试验常见问题及考虑
- Author:
WU Shuang
- Publication Type:Journal Article
- Keywords:
SARS-CoV-2 vaccine;
Challenge test;
Animal models
- From:
Chinese Journal of Biologicals
2023;36(9):1149-1152
- CountryChina
- Language:Chinese
-
Abstract:
Animal challenge test is an effective means to study the efficacy of severe acute respiratory symptom coronavirus 2(SARS-CoV-2)vaccine. The appropriate animal models and reasonable experimental design play an important role in obtaining efficacy and safety information,as well as supporting clinical trials. At present,common non-clinical animal models include transgenic mice,non-human primates,hamsters,ferrets and so on. This paper reviews the common animal models used in non-clinical trials and the problems encountered in their application.