Research progress on regulation of Staphylococcus aureus Ebh protein by ArlRS two-component system
10.13200/j.cnki.cjb.003976
- VernacularTitle:ArlRS双组分系统对金黄色葡萄球菌Ebh蛋白调控作用的研究进展
- Author:
GUAN Xiaowen
- Publication Type:Journal Article
- Keywords:
Staphylococcus aureus;
ArlRS two-component system;
Ebh protein;
Pathogenicity
- From:
Chinese Journal of Biologicals
2023;36(8):1010-1013+1020
- CountryChina
- Language:Chinese
-
Abstract:
Staphylococcus aureusis a major cause of hospital and community acquired infection,which can express many kinds of cell wall-related and extracellular virulence factors,causing a variety of infectious diseases. Ebh protein is involved in the adhesion,aggregation and biofilm formation of Staphylococcus aureus,and thus closely related to its strong pathogenicity. The pathogenesis of Staphylococcus aureus is controlled collaboratively by different two-component signal transduction systems and transcriptional regulation factors,among which ArlRS is the key two-component system(TCS)necessary for the adhesion,biofilm formation and virulence. At the same time,ArlRS regulates Ebh protein through global regulation factor MgrA,thus affecting the role of Staphylococcus aureus in human infectious diseases. In this paper,the regulatory mechanism was reviewed.
