Research progress on immunogenicity of therapeutic antibodies
10.13200/j.cnki.cjb.003943
- VernacularTitle:治疗性抗体免疫原性的研究进展
- Author:
YU Xingyan
- Publication Type:Journal Article
- From:
Chinese Journal of Biologicals
2023;36(7):868-873
- CountryChina
- Language:Chinese
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Abstract:
Therapeutic antibodies have achieved ideal results in clinical practice,while the immunogenicity of antibody drugs may trigger anti-drug immune response in the body,thus inducing the formation of anti-drug antibody(ADA).ADA affects the clearance and bioavailability of drugs through neutralizing/non-neutralizing drug activities,and changes the pharmacokinetic and pharmacodynamic characteristics of drugs,which can interfere or block the therapeutic effect of drugs and may lead to adverse reactions to varying degrees in clinical practice,and can interfere with the effectiveness evaluation and screening of candidate molecules in preclinical studies.Therefore,this paper reviewed the factors affecting immunogenicity,the types and formation mechanism of ADA,the detection methods of ADA,the strategies to mitigate immunogenicity and the development of preclinical animal models for highly immunogenic drugs,so as to provide a reference for the development of therapeutic antibodies.
