Prevention and Treatment of Obesity Type 2 Diabetes Mellitus by Traditional Chinese Medicine Through AMPK Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20231018
- VernacularTitle:中医药调控AMPK信号通路防治肥胖2型糖尿病的研究进展
- Author:
Junlong WANG
1
;
Huiyu JIA
1
;
Zhihai FENG
2
;
Li LI
3
Author Information
1. Henan University of Chinese Medicine， Zhengzhou 450000， China
2. The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000， China
3. The Affiliated Hospital of Hangzhou Normal University，Hangzhou 310000， China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
obesity type 2 diabetes mellitus;
adenosine phosphate activated protein kinase （AMPK） signaling pathway;
mechanism of action;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(21):264-273
- CountryChina
- Language:Chinese
-
Abstract:
Obesity type 2 diabetes mellitus （T2DM） strengthens insulin resistance （IR） and metabolic abnormalities and significantly increases the risk of heart disease， cancer， and other diseases， and it is characterized by IR and malnutrition. As a metabolic regulation center， adenosine phosphate activated protein kinase （AMPK） mainly responds to the changes in intracellular serine/threonine kinase adenosine monophosphate （AMP） levels. After its activation， AMPK converts the cell metabolism mode from synthesis to decomposition to improve energy metabolism and acts on pathological conditions such as inflammation， ischemia， obesity， and aging. In recent years， a large number of studies have found that AMPK is an important target for the treatment of obesity T2DM. Traditional Chinese medicine（TCM） monomers/extracts and TCM formulas mainly affect the mammalian target of rapamycin （mTOR）， recombinant sirtuin 1 （SIRT1）， nuclear factor erythroid 2-related factor 2 （Nrf2）， nuclear factor kappa-B （NF-κB）， and other key signaling factors by regulating the AMPK signaling pathway， so as to achieve a variety of effects such as regulating metabolism and autophagy， reducing oxidative stress and inflammatory response， and treating obesity T2DM. It also has advantages such as multiple targets， comprehensiveness， and low toxicity. The regulation of the AMPK pathway by TCM in the prevention and treatment of obesity T2DM has become an important research direction at the present and in the future， but there is no systematic summary and induction in this field. Therefore， this article attempts to summarize the composition and regulatory mechanisms of the AMPK signaling pathway in affecting obesity. It provides a review of the current research status of TCM in regulating the AMPK signaling pathway for the prevention and treatment of obesity T2DM， so as to provide a reference for the diagnosis and treatment of obesity T2DM in TCM and the development of new drugs.
