Traditional Chinese Medicine Intervention in Ulcerative Colitis Based on TLR4 Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20232190
- VernacularTitle:基于TLR4信号通路的中医药干预溃疡性结肠炎研究进展
- Author:
Mingyao XU
1
;
Sheng XIE
2
;
Liqun LI
2
;
Xiaoyan HUANG
2
;
Xin LIU
1
;
Jinxin WANG
1
;
Chengning YANG
2
Author Information
1. Graduate School of Guangxi University of Traditional Chinese Medicine（TCM），Nanning 530001， China
2. The First Affiliated Hospital of Guangxi University of TCM，Nanning 530001， China
- Publication Type:Journal Article
- Keywords:
ulcerative colitis （UC）;
Toll-like receptor 4 （TLR4） signaling pathway;
traditional Chinese medicine;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(21):228-237
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis （UC） is a disease that affects the mucosal and submucosal layers of the colon and is characterized by inflammation of the intestinal mucosa. The incidence of UC is increasing year by year， and it is complex and refractory， severely impacting the physical and mental health of patients. The pathological mechanism of this disease is complex， with immune responses and uncontrollable inflammatory reactions in the intestine being important physiopathologic mechanisms. Toll-like receptor 4 （TLR4）， as a transmembrane signaling receptor， plays a key role in mediating immune responses and inflammatory reactions in the development of UC. Currently， the treatment of UC mainly relies on salicylic acids， glucocorticoids， and other agents to reduce intestinal inflammation. While these drugs can partially inhibit the progression of the disease， they often come with significant adverse effects and the potential for relapse upon discontinuation. Traditional Chinese medicine （TCM） offers multiple pathways， effects， and targets for regulating the TLR4 pathway， suppressing inflammatory responses， and effectively intervening in the progression of UC. This approach has become a hot topic in the prevention and treatment of UC. Numerous studies have shown that TCM treatment of UC has unique advantages. TCM can enhance immune defenses， suppress inflammatory responses， promote intestinal mucosal healing， and maintain the balance of the intestinal microbiota by regulating the TLR4 signaling pathway， thereby effectively treating UC， with substantial progress achieved. However， there is currently a lack of comprehensive reviews on the role of TCM in regulating the TLR4 signaling pathway for the treatment of UC. Therefore， this article systematically summarized the relationship between the TLR4 signaling pathway and UC， as well as the role of TCM in this context， by reviewing relevant literature from recent years， aiming to provide new insights into the potential treatment and new drug development for UC.
