Mechanism of Bone Homeostasis Regulation by Autophagy in Osteoporosis and Intervention of Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20222290
- VernacularTitle:自噬调节骨稳态在骨质疏松症中的作用机制及中医药干预研究进展
- Author:
Jian MO
1
;
Xiangshan CHEN
2
;
Xiaoyun ZHANG
1
Author Information
1. Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine， Nanning 530011， China
2. Guangxi University of Chinese Medicine， Nanning 530000， China
- Publication Type:Review
- Keywords:
autophagy;
osteoporosis;
bone homeostasis;
traditional Chinese medicine;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(21):204-212
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis （OP） is a systemic metabolic bone disease caused by various factors， with a high incidence， and its pathogenesis is not yet clear. There is no specific drug for prevention and treatment， making it a significant global public health issue. In recent years， research has found that autophagy plays a role in the development of OP， and intervention in autophagy has become a hot topic in OP treatment. With further research， there has been a gradual increase in studies related to autophagy regulation by traditional Chinese medicine （TCM） to treat OP， and the treatment efficacy has been recognized. However， there is still a lack of systematic reviews on the mechanisms of autophagy in OP and the specific targets of TCM intervention in autophagy for OP treatment. Therefore， this article systematically reviewed the impact of autophagy on bone marrow mesenchymal stem cells （BMSCs）， osteoblasts， osteoclasts， and bone cells in the development of OP， as well as studies on TCM intervention in cell autophagy for OP treatment， aiming to provide a theoretical reference for the treatment of OP and further research in this field.
