Research progress of bacterial flagellin as a vaccine adjuvant
10.13200/j.cnki.cjb.003919
- VernacularTitle:细菌鞭毛蛋白作为疫苗佐剂应用的研究进展
- Author:
XIANG Tingting
- Publication Type:Journal Article
- Keywords:
Flagellin;
Adjuvant;
Vaccine;
Bacteria;
Fusion protein
- From:
Chinese Journal of Biologicals
2023;36(6):764-768
- CountryChina
- Language:Chinese
-
Abstract:
Vaccines play an important role in the prevention and control of infectious diseases. Bacterial flagellin can activate Toll like receptor 5(TLR5) and NOD like receptor C4(NLRC4) in host cells,and has immune adjuvant effect. As a new immune adjuvant,flagellin can not only share with antigen protein,but also fuse with antigen protein,which can significantly improve the immune effect. At the same time,it has achieved good application effect in mucosal immunity and antitumor immunity,becoming a hot spot in the research and development of vaccine adjuvants. This review mainly discussed the research progress on application of bacterial flagellin as vaccine adjuvant,so as to provide new ideas for the development of flagellin adjuvant vaccine.
