Research progress on role of apolipoprotein B mRNA-editing catalytic polypeptide 3B in occurrence and development of hematological tumors
10.13200/j.cnki.cjb.003913
- VernacularTitle:载脂蛋白B mRNA编辑酶催化亚基3B在血液肿瘤发生发展中作用的研究进展
- Author:
WANG Li
- Publication Type:Journal Article
- From:
Chinese Journal of Biologicals
2023;36(6):737-741
- CountryChina
- Language:Chinese
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Abstract:
The incidence of hematological tumors is increasing year by year. Childhood leukemia is a malignant tumor with the highest incidence in children. A variety of genetic mutations are closely related to the occurrence and development of hematological tumors. Apolipoprotein B mRNA-editing catalytic polypeptide 3B(APOBEC3B),a member of the cytosine deaminase family,can induce mutations in target DNA or RNA,which is one of the causes of tumor genome damage.APOBEC3B is highly expressed in many hematological tumors. This paper mainly reviewed the research progress on the role of APOBEC3B in hematological tumors,so as to provide potential targets for targeted therapy and accurate personalized therapy of hematological tumors.
