Clinical characteristics of liver injury caused by anti-tuberculosis drugs in newly treated pulmonary tuberculosis patients co-infected with hepatitis B virus
10.3969/j.issn.1006-2483.2023.05.036
- VernacularTitle:初治肺结核并乙型肝炎病毒携带者抗结核药物致肝损伤的临床特征分析
- Author:
Qing ZHOU
1
;
Jing REN
1
;
Ting YUAN
1
;
Yingzheng TAN
1
;
Dan LI
1
;
Jingli FU
1
;
Shuang PENG
1
Author Information
1. Department of Infection , Zhuzhou Central Hospital , Zhuzhou , Hunan 412000 , China
- Publication Type:Journal Article
- Keywords:
Newly treated pulmonary tuberculosis;
Hepatitis B virus;
Anti-tuberculosis drugs;
Pulmonary tuberculosis;
Liver injury
- From:
Journal of Public Health and Preventive Medicine
2023;34(5):157-160
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics of drug-induced liver injury caused by anti-tuberculosis drugs in newly treated pulmonary tuberculosis patients with hepatitis B virus (HBV). Methods A total of 133 patients with pulmonary tuberculosis and HBV who were treated in Zhuzhou Central Hospital from January 2018 to early January 2022 were selected, and all were treated with conventional anti-tuberculosis 2HRZE/4HR regimen. According to the liver injury, the patients were divided into liver injury group and no liver injury group. Univariate analysis was used to analyze the related factors of liver injury caused by anti-tuberculosis drugs, and multivariate logistic regression analysis was used to analyze the independent risk factors of liver injury caused by anti-tuberculosis drugs. Results Among 133 cases of newly treated pulmonary tuberculosis patients with HBV, 24 cases had liver injury caused by anti-tuberculosis drugs, accounting for 18.05%; 109 patients had no liver injury caused by anti-tuberculosis drugs, accounting for 81.95%. Univariate analysis showed that there were significant differences in smoking history, drinking history, diabetes history, hypertension history, anti-tuberculosis treatment plan, malnutrition, and use of hepatoprotective drugs between the liver injury group and the no liver injury group (P<0.05). Multivariate logistic regression analysis showed that smoking history, drinking history, diabetes history, hypertension history, PZA-containing regimen, malnutrition, and no use of hepatoprotective drugs were independent risk factors for liver injury caused by anti-tuberculosis drugs. Conclusion Smoking history, drinking history, diabetes history, hypertension history, PZA-containing regimen, malnutrition, and no use of hepatoprotective drugs are the risk factors for drug-induced liver injury caused by anti-tuberculosis drugs in newly treated pulmonary tuberculosis patients with HBV.
