A retrospective cohort study on blood lipid changes and their influencing factors in HIV/AIDS patients after receiving antiretroviral therapy in Wuhan
10.3969/j.issn.1006-2483.2023.05.025
- VernacularTitle:武汉市HIV/AIDS患者接受抗病毒治疗后血脂变化及危险因素
- Author:
Yanhe LUO
1
;
Xiaosheng MENG
2
;
Xiaoli YU
1
;
Ke HONG
1
;
Yawu ZHANG
1
;
Lianguo RUAN
1
Author Information
1. Wuhan Jinyintan Hospital , Tongji Medical College of Huazhong University of Science and Technology；Hubei Clinical Research Center for Infectious Diseases；Wuhan Research Center for Communicable Disease Diagnosis and Treatment, Chinese Academy of Medical Sciences；Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology and Wuhan Jinyintan Hospital, Chinese Academy of Sciences , Wuhan , Hubei 430023 , China
2. Tongji Medical College Huazhong University of Science and Technology , Wuhan , Hubei 430030 , China
- Publication Type:Journal Article
- Keywords:
HIV/AIDS patients;
Blood lipids;
HAART
- From:
Journal of Public Health and Preventive Medicine
2023;34(5):112-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence and influencing factors of HIV/AIDS patients with hyperlipidemia before and after receiving antiviral therapy in Wuhan. Methods A retrospective cohort study was used to analyze the data of HIV/AIDS patients in Wuhan from 2004 to 2021. Elevated levels of either TG or TC were determined as hyperlipidemia. Logistic regression model was used to analyze the influencing factors of baseline hyperlipidemia, and Cox proportional risk model was used to analyze the influencing factors of new-onset hyperlipidemia after receiving antiviral therapy. Results A total of 7 562 HIV/AIDS patients were enrolled, 30.61% (2 315/7 562) with hyperlipidemia at baseline and 69.39% (5 247/7 562) without hyperlipidemia. The mean person-years of follow-up for those patients without hyperlipidemia at baseline were 3.48, of whom 33.14% (1 739/5 247) developed hyperlipidemia during follow-up, with an overall density of 9.53/100 person-years. Multivariate logistic regression analysis showed that age ≥30 years and BMI ≥24 kg/m2 were positively correlated with baseline hyperlipidemia, while CD4 cell count ≥ 200 μL was negatively correlated with baseline hyperlipidemia. Multivariate Cox model analysis showed that new-onset hyperlipidemia after receiving antiviral therapy was significantly positively correlated with BMI between 18.5-23.9 and ≥24 kg/m2, the initial antiviral treatment regimen containing LPV/r, efavirenz and other factors A baseline CD4 cell count of 200 to 349 cells /μL was negatively correlated with new-onset hyperlipidemia. Conclusion HIV/AIDS patients with high BMI and an initial antiviral regimen including Kaletra or efavirenz have a significantly higher risk of hyperlipidemia. Follow-up monitoring of blood lipid in these patients should be strengthened.
