Effect of poria cocos on gastrointestinal motility in mice
10.3969/j.issn.1006-2483.2023.05.008
- VernacularTitle:茯苓对小鼠胃肠动力调节作用的研究
- Author:
Min FENG
1
;
Ziming JIA
1
;
Ming WAN
1
;
Bolin FAN
1
;
Xiaoqiao TANG
1
;
Wenhua CHENG
1
;
Fanzhong SUN
1
Author Information
1. Hubei Provincial Key Laboratory of Applied Toxicology , Hubei Provincial Center for Disease Control and Prevention , Wuhan , Hubei 430075, China
- Publication Type:Journal Article
- Keywords:
Poria cocos;
Mice;
Gastrointestinal motility;
Propulsion rate
- From:
Journal of Public Health and Preventive Medicine
2023;34(5):39-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the regulatory effect of poria cocos on gastrointestinal motility in mice. Methods A total of 130 Kunming mice were randomly divided into negative control group, low-dose and high-dose groups of raw poria cocos powder, low-dose and high-dose groups of cooked poria cocos powder, low-dose and high-dose groups of poria cocos surrogate culture powder, low-dose, medium-dose and high-dose groups of poria cocos water extract, and low-dose, medium-dose and high-dose groups of poria cocos alcohol extract, with 10 mice in each group. The animals were administered by gavage for 7 days, once a day. After the last administration, the intestinal propulsion function test and gastric solid emptying test were conducted to observe the regulating effect of poria cocos on gastrointestinal motility of mice. Results Compared with the negative control group, the small intestine propulsion rate in the low-dose group of poria cocos surrogate culture powder was significantly increased (P<0.01). Except the high-dose group of raw poria cocos powder, the other poria cocos groups had higher gastric residual rate (P<0.05). Conclusion Poria cocos does not promote intestinal propulsion of mice under normal physiological condition, but it can inhibit gastric empting and exert a moderating effect on gastrointestinal function in normal mice.
