Changes in the disease burden of liver cancer caused by nonalcoholic steatohepatitis in China 1990-2019
10.3969/j.issn.1006-2483.2023.05.005
- VernacularTitle:1990-2019年中国非酒精性脂肪肝炎导致的肝癌疾病负担变化分析
- Author:
Xuhong CHEN
1
;
Mengdie LI
1
;
Yi YUAN
1
;
Liping ZHANG
1
Author Information
1. Weifang Medical University, Weifang , Shandong 261053, China
- Publication Type:Journal Article
- Keywords:
Nonalcoholic steatohepatitis;
Liver cancer;
Disease burden;
Incidence;
Mortality;
Disability-adjusted life year (DALY)
- From:
Journal of Public Health and Preventive Medicine
2023;34(5):25-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To describe and analyze the disease burden and its changing trend of liver cancer caused by nonalcoholic steatohepatitis (NASH) in China from 1990 to 2019, and to provide reference for reducing the morbidity and mortality of liver cancer in China. Methods Based on data from the Global Burden of Disease (GBD2019) study, different gender and age groups were selected. The morbidity, mortality, and disability adjusted life year (DALY) rate were used to analyze the disease burden of liver cancer caused by NASH in China from 1990 to 2019. The time trend was analyzed by using the Joinpoint regression model, and the annual percent of change (APC) and annual average percentage change (AAPC) of morbidity, mortality and DALY rate were calculated. Results Compared with 1990, the incidence rate, mortality rate and DALY rate of liver cancer caused by NASH in 2019 decreased by 4.05%, 12% and 25.79%, respectively. Age-standardized morbidity, standardized mortality and standardized DALY rates decreased by 49.50%, 54.72% and 58.45%, respectively. In 2019, the incidence rate, mortality data and DALY rate of liver cancer caused by NASH increased with age, and the highest mortality rate was among people over 85 years old. The average annual change percentage (AAPC) of age-standardized incidence rate, standardized mortality rate and standardized DALY rate of liver cancer caused by NASH from 1990 to 2019 were -2.65% ［95% CI（-3.09%，-2.21 %），P<0.001］, -2.86%［95% CI（-3.34%，-2.38 %），P<0.001］, and -2.91%［95% CI（-3.23%，-2.58%），P<0.001］，respectively. The AAPC of all indexes in males was higher than that in females. Conclusion From 1990 to 2019, the disease burden of liver cancer caused by NASH in China showed an overall downward trend. The AAPC of all indexes in males is higher than that in females, and the elderly population is a high-risk group.
