Study progress on traditional Chinese medicine monomer intervening in pancreatic cancer by regulating PI3K/Akt signaling pathway
- VernacularTitle:中药单体调控PI3K/Akt信号通路干预胰腺癌的研究进展
- Author:
Mingyao XU
1
;
Jing HUANG
1
;
Zhiwen SHEN
1
;
Xiaoning ZHANG
1
;
Xin LIU
1
;
Jiaqi YIN
1
;
Zhu LIU
1
;
Liqun LI
2
;
Sheng XIE
2
Author Information
1. Graduate School of Guangxi University of Chinese Medicine，Nanning 530001，China
2. Dept. of Spleen and Stomach Diseases，the First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530001，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine monomer;
pancreatic cancer;
PI3K/Akt signaling pathway;
mechanism of action
- From:
China Pharmacy
2023;34(19):2427-2432
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is one of the most destructive malignant tumors； the pathogenesis of this disease is complex and is closely related to genetic susceptibility， chronic pancreatitis， and gene mutations in signaling pathways. The phosphoinositide 3- kinase （PI3K）/protein kinase B （Akt） signaling pathway is a classical cancer signaling pathway that is aberrantly activated in pancreatic cancer cells. In recent years， it has been found that traditional Chinese medicine （TCM） monomers show special activity in the treatment of pancreatic cancer and can be potential drug for the treatment of pancreatic cancer. Based on PI3K/Akt signaling pathway， this paper summarizes the mechanism of TCM monomer intervening in pancreatic cancer and finds that TCM monomer of alkaloids （sinomenine， dictamnine， dauricine， etc.）， terpenoids （saikosaponin A， linderalactone， isoalantolactone， etc.）， phenols （6-gingerol， curcumin， pterostilbene， etc.）， flavonoids （fisetin， kaempferol， quercetin， etc.） and quinones （β-hydroxyisovaleryl shikonin， rhein， lucidone， etc.） can inhibit the proliferation， invasion and migration of pancreatic cancer cells， regulate autophagy and apoptosis， and then inhibit the pathological process of pancreatic cancer by inhibiting PI3K/Akt signaling pathway.
