Research progress on receptor activity-modifying proteins and their application prospects in disease prevention
10.13200/j.cnki.cjb.003896
- VernacularTitle:受体活性调节蛋白的研究进展及其在疾病预防中的应用前景
- Author:
QIAN Rui
- Publication Type:Journal Article
- Keywords:
Receptor activity-modifying proteins(RAMPs);
G-protein-coupled receptors(GPCRs);
Disease prevention;
Pathology;
Signaling pathway
- From:
Chinese Journal of Biologicals
2023;36(5):626-630
- CountryChina
- Language:Chinese
-
Abstract:
Receptor activity-modifying proteins(RAMPs) are type I transmembrane proteins,which are activity-modifying proteins of a variety of G-protein-coupled receptors(GPCRs).RAMPs are related to physiological and pathological phenomena such as neurological diseases,cardiovascular diseases,renal function,skeletal development and obesity,and of great significance for disease prevention,which are potential targets for the treatment of various diseases and also closely related to the prognosis of diseases.At present,there are few studies on proteins that may regulate the expression of RAMPs.This paper focuses on the sterol regulatory element-binding factor-2(SREBF-2) that may regulate the transcription and expression of RAMP3, and reviews the research progress of RAMPs in biology,pathology and pharmacology,providing a reference for the further research on RAMPs and the prevention and detection of related diseases.
