Effect of mitomycin C instilled immediately after TUR added with low dose BCG maintenance therapy to prevent recurrence of superficial bladder cancer
- VernacularTitle:丝裂霉素C加卡介苗灌注预防浅表性膀胱癌术后复发疗效观察
- Author:
Lihong YE
;
Yongliang CHEN
;
Shuixiang TAO
;
Songxi QIAN
- Publication Type:Journal Article
- Keywords:
bladder tumor, bacillus Calmette-Guérin vaccine (BCG), mitomycin C (MMC)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2003;9(12):730-731
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe therapeutic effects of intravesical instillation of mitomycin C (MMC) immediately after TUR added with low dose BCG maintenance therapy to prevent recurrence of superficial bladder cancer. Methods 83 patients with superficial bladder cancer were randomly divided into two groups, 50 cases were managed with intravesical instillation of mitomycin C immediately after TUR added with low dose BCG maintenance therapy (group A), 33 cases were treated with traditional method of MMC therapy (group B) to prevent recurrence of superficial bladder cancer. Results After 12-66 months (mean 32 months) following up, 3 patients had tumor recurrence in the group A and 7 patients in the group B, the rate of tumor recurrence of the group A was 6.0% (3/50) and that of the group B was 21.2%(7/33), and there was a significantly difference between two groups (P<0.05). Side effects of the group B were obviously more than that of the group A. Conclusion Intravesical instillation of MMC immediately after TUR added with low dose BCG maintenance therapy is effective to prevent patients with superficial bladder cancer from recurrence.
