Progress of the mechanism of energy metabolism reprogramming regulated by long non-coding RNA in cancer
10.3760/cma.j.cn115355-20230109-00016
- VernacularTitle:长链非编码RNA调控肿瘤能量代谢重编程机制的研究进展
- Author:
Yiting DONG
1
;
Wenxue WANG
;
Yaping JIANG
Author Information
1. 青岛大学附属医院口腔医学中心，青岛 266000
- Keywords:
Neoplasms;
Long non-coding RNA;
Energy metabolism;
Targeting therapy
- From:
Cancer Research and Clinic
2023;35(8):637-640
- CountryChina
- Language:Chinese
-
Abstract:
Although it is widely believed that abnormal energy metabolism exists in cancer cells and affects the biological behavior of cancers, the exact mechanism of energy metabolic reprogramming and specific mechanism of its effect on proliferation, invasion and metastasis of cancer cells have not been clarified. In recent years, studies have shown that long non-coding RNA (lncRNA) can affect energy metabolism, development and progression of cancer cells through binding to specific nucleic acids and proteins at the transcriptional and post-transcriptional stages, and specifically through transcriptional interference, epigenetic regulation of genes, changes in protein activity, competitive binding to microRNA (miRNA) and other related mechanisms. The further study on the mechanism of lncRNA regulating energy metabolism reprogramming of cancer cells is expected to find new markers and targets for diagnosis and treatment of cancer. This paper reviews the current research progress of the mechanism of lncRNA regulating metabolic reprogramming of glucose, fatty acid, protein and nucleotide in cancer, and provides a new idea of lncRNA's regulation of energy metabolism pathways for targeted anticancer therapy.
